SMILE

Stochastic Models for the Inference of Life Evolution

Presentation

SMILE is an interdisciplinary research group gathering probabilists, statisticians, bio-informaticians and biologists.
SMILE is affiliated to the Stochastics and Biology group of LPSM (Lab of Probability, Statistics and Modeling) at Sorbonne Université (ex Université Pierre et Marie Curie Paris 06).
SMILE is hosted within the CIRB (Center for Interdisciplinary Research in Biology) at Collège de France.
SMILE is supported by Collège de France and CNRS.
Visit also our homepage at CIRB.

Recent contributions of the SMILE group related to SARS-Cov2 and COVID-19.

Directions

SMILE is hosted at Collège de France in the Latin Quarter of Paris. To reach us, go to 11 place Marcelin Berthelot (stations Luxembourg or Saint-Michel on RER B).
Our working spaces are rooms 107, 121 and 122 on first floor of building B1 (ask us for the code). Building B1 is facing you upon exiting the traversing hall behind Champollion's statue.

Contact

You can reach us by email (amaury.lambert - at - upmc.fr) or (smile - at - listes.upmc.fr).

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Publication

2018

Pathogen evolution in finite populations: slow and steady spreads the best

The theory of life history evolution provides a powerful framework to understand the evolutionary dynamics of pathogens in both epidemic and endemic situations. This framework, however, relies on the assumption that pathogen populations are very large and that one can neglect the effects of demographic stochasticity. Here we expand the theory of life history evolution to account for the effects of finite population size on the evolution of pathogen virulence. We show that demographic stochasticity introduces additional evolutionary forces that can qualitatively affect the dynamics and the evolutionary outcome. We discuss the importance of the shape of pathogen fitness landscape and host heterogeneity on the balance between mutation, selection and genetic drift. In particular, we discuss scenarios where finite population size can dramatically affect classical predictions of deterministic models. This analysis reconciles Adaptive Dynamics with population genetics in finite populations and thus provides a new theoretical toolbox to study life-history evolution in realistic ecological scenarios.

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March 2, 2016

Alice and the Enigmatic Tree of Rabbits

Wonderland is far away, and the white rabbit is sad: its phylogenetic tree is unbalanced, and he is very isolated at the end of its branch! Hopefully, Alice is here, and ready to help him disentangle the factors responsible for macroevolutionary patterns of species diversification!

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May 3, 2020

Enquête Alcov2

Appel à participation à l'enquête Alcov2 pour l'étude de la transmission du nouveau coronavirus au sein des foyers français menée par une équipe CNRS/Sorbonne Université/Collège de France.

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September 23, 2019

SMILE from an art student's viewpoint

A view of the SMILE group by William Antoine, an EPSAA student (École professionnelle supérieure d'arts graphiques et d'architecture).

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June 4, 2018

Entretien avec Hélène et Amaury

(Movie in french) Entretien avec Hélène Morlon et Amaury Lambert. Mathématicienne de formation, Hélène Morlon est responsable d'une équipe de recherche (Modélisation de la Biodiversité) à l'Institut de Biologie de l'ENS Paris. Amaury Lambert est mathématicien, chercheur au Centre Interdisciplinaire de Recherche en Biologie (Collège de France)

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October 19, 2020

Amaury interviewed by the French mathematical society

Amaury Lambert est mathématicien, professeur à Sorbonne Université et professeur associé au département de biologie de l’École normale supérieure. Il anime l’équipe SMILE au Collège de France. Sa recherche se situe à l’intersection de l’évolution, de l’écologie et des probabilités. Il nous explique ci-dessous sa réponse de mathématicien travaillant à l’interface avec la biologie face à la crise sanitaire.

Upcoming seminars

Resources

Planning des salles du Collège de France.
Intranet du Collège de France.